کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8350417 | 1541849 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute social defeat stress increases the conditioned rewarding effects of cocaine in adult but not in adolescent mice
ترجمه فارسی عنوان
استرس شکست حاد، اثرات متقاعد کننده شرط کوکائین را در بزرگسالان افزایش می دهد، اما نه در موش های نوجوان
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کلمات کلیدی
شکست حاد اجتماعی، موش، کوکائین، ترجیح محل مواجه، کورتیکواسترون،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Stressful experiences modify activity in areas of the brain involved in the rewarding effects of psychostimulants. In the present study we evaluated the influence of acute social defeat (ASD) on the conditioned rewarding effects of cocaine in adolescent (PND 29-32) and adult (PND 50-53) male mice in the conditioned place preference (CPP) paradigm. Experimental mice were exposed to social defeat in an agonistic encounter before each session of conditioning with 1Â mg/kg or 25Â mg/kg of cocaine. The effects of social defeat on corticosterone levels were also evaluated. Adult mice exposed to ASD showed an increase in the conditioned reinforcing effects of cocaine. Only these mice developed cocaine-induced CPP with the subthreshold dose of cocaine, and they needed a higher number of extinction sessions for the 25Â mg/kg cocaine-induced CPP to be extinguished. In adolescent mice, on the other hand, ASD reduced the conditioned reinforcing effects of cocaine, since CPP was not produced with the lower dose of cocaine and was extinguished faster when they were conditioned with 25Â mg/kg. Adult mice exposed to social defeat displayed higher levels of corticosterone than their controls and adolescent mice. Our results confirm that the effect of social defeat stress on the acquisition and reinstatement of the CPP induced by cocaine varies depending on the age at which this stress is experienced.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 135, August 2015, Pages 1-12
Journal: Pharmacology Biochemistry and Behavior - Volume 135, August 2015, Pages 1-12
نویسندگان
S. Montagud-Romero, M.A. Aguilar, C. Maldonado, C. Manzanedo, J. Miñarro, M. RodrÃguez-Arias,