کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8350946 | 1541860 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice
ترجمه فارسی عنوان
محروم شدن از خواب، از بین رفتن تهویه محیط زیست ناشی از کوکائین در موش کاسته می شود
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
خواب کوکائین، حساسیت رفتاری، تهویه مطبوع، انقراض، موش،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Persistence of a drug-environment conditioning induced by repeated psychostimulant treatment is thought to play a key role in the addictive cycle. In addition, sleep disorders are a common feature in patients with addictive disorders. Sleep deprivation shares similar neurobiological effects with psychostimulants. Therefore, we investigated whether sleep deprivation would impair the extinction of previously established conditioning between the drug effect and the environmental cues. Four cohorts of male adult mice underwent a behavioral sensitization procedure pairing drug (cocaine at 15Â mg/kg, i.p.) or saline with environment (open-field apparatus). The extinction of conditioned locomotion was evaluated after control (home-cage maintained) or sleep deprivation (gentle handling method for 6Â h) conditions. Sleep deprivation both postponed the initiation and impaired the completeness of extinction of the conditioned locomotion promoted by previous drug-environment conditioning in cocaine-sensitized animals. While the cocaine control group required 5 free-drug sessions of exposure to the open-field apparatus to complete extinction of conditioned locomotion, the cocaine pre-treated group that experienced sleep deprivation before each extinction session still significantly differed from its respective control group on Day 5 of extinction. The possibility that the sleep condition can influence the extinction of a long-lasting association between drug effects and environmental cues can represent new outcomes for clinically relevant phenomena.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 124, September 2014, Pages 13-18
Journal: Pharmacology Biochemistry and Behavior - Volume 124, September 2014, Pages 13-18
نویسندگان
L.F. Berro, A.W. Hollais, C.L. Patti, D.F. Fukushiro, E. Mári-Kawamoto, F. Talhati, J.M. Costa, K.A. Zanin, L.B. Lopes-Silva, L.M. Ceccon, R. Santos, R. Procópio-Souza, T.F. Trombin, T.S. Yokoyama, R. Wuo-Silva, S. Tufik, M.L. Andersen,