کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8351021 | 1541860 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cross-substitution of Î9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Synthetic indole-derived cannabinoids, originally developed to probe cannabinoid CB1 and CB2 receptors, have become widely abused for their marijuana-like intoxicating properties. The present study examined the effects of indole-derived cannabinoids in rats trained to discriminate Î9-tetrahydrocannabinol (Î9-THC) from vehicle. In addition, the effects of Î9-THC in rats trained to discriminate JWH-018 from vehicle were assessed. Adult male Sprague-Dawley rats were trained to discriminate 3Â mg/kg Î9-THC or 0.3Â mg/kg JWH-018 from vehicle. JWH-018, JWH-073, and JWH-210 fully substituted in Î9-THC-trained rats and Î9-THC substituted in JWH-018-trained rats. In contrast, JWH-320, an indole-derived cannabinoid without affinity for CB1 receptors, failed to substitute for Î9-THC. Pre-treatment with 1Â mg/kg rimonabant significantly reduced responding on the JWH-018-associated lever in JWH-018-trained rats. These results support the conclusion that the interoceptive effects of Î9-THC and synthetic indole-derived cannabinoids show a large degree of overlap, which is predictive of their use for their marijuana-like intoxicating properties. Characterization of the extent of pharmacological differences among structural classes of cannabinoids, and determination of their mechanisms remain important goals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 124, September 2014, Pages 123-128
Journal: Pharmacology Biochemistry and Behavior - Volume 124, September 2014, Pages 123-128
نویسندگان
Jenny L. Wiley, Timothy W. Lefever, Ricardo A. Cortes, Julie A. Marusich,