Doxorubicin-induced behavioral disturbances in rats: Protective effect of melatonin and captopril

Chronic administration of captopril or melatonin has shown anxiolytic effect in the model of doxorubicin‐induced anxiety. It does not seem unreasonable to suppose that this protective effect of captopril or melatonin against anxiety development might have been related to the antioxidative effects of both substances.