Post-translational regulation of cold acclimation response

► Post-translational modifications regulate protein function. ► Many proteins involved in cold acclimation are post-translationally modified. ► Different kinds of post-translational modifications mediate cold acclimation. ► Reversible post-translational modifications constitute versatile mechanisms to adapt to freezing temperatures. ► Post-translational regulation is essential for proper development of cold acclimation.