Mortal hyperkalemia disturbances in rats are NO-system related. The life saving effect of pentadecapeptide BPC 157

► Mortal hyperkalemia disturbance in rats are NO-system related. ► BPC 157-treatment reduced hyperkalemic cell depolarization to 23% of started values. ► BPC-157 alone cause depolarization of HEK293 cells. ► This effect was blocked by unspecific potassium channel inhibitor BaCl2. ► BPC 157 acts through modulation of NO system and potassium conductivness.