L'inversion dorsoventrale : un essai de synthèse

The invertebrates, with known exception of echinoderms, are hyponeurian and protostomian. By contrast, echinoderms, chordates and vertebrate are epineurian and deuterostomian. Convinced of the uniqueness origin of all species, Etienne Geoffroy Saint Hilaire (1772-1844), had postulated a complete inversion of body plan to explain this difference. He had to face up to the hostility of the fixist Georges Cuvier (1763-1832). Much later, famous embryologists such as Maurice Caullery still believed that this idea was erroneous. However, the progress of comparative embryology and of developmental biology gradually contributed to validate this idea. Based upon ancient and recent literature review, and re-examination of arthropods (Acanthoscelides obtectus Say), amphibians (Discoglossus), echinoderms (sea urchin) and mammals (rodents) embryos, we can raise up difference and common points of the gastrulation processes. The dorsoventral gradient is ensured by the couple Dpp (dorsal in arthropods)/SOG/chordin (ventral in arthropods), which appears as “inverted” in epineurians. Blastopore invagination occurs in arthopods in the ventral region, opposite to the vitellus mass (initially diffuse, then predominant on the dorsal side), whereas it occurs at the vegetative side in other hyponeurians and epineurians. It has been accepted that the BMP inhibits oral development in protostomian, whereas it activates it in Chordates. Therefore we assume, as Lowe does, that the oral cavity of deuterostomians might constitute a new structure related to the branchial system. The comparative analysis of the blastopore' orientation, the sperm penetration site, and the polarity axes of various embryos species allows to follow the different modifications and to hypothesize their relative chronology during evolution.