کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8497648 | 1553545 | 2018 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
microRNA-19a as a negative regulator in TLR signaling pathway by direct targeting myeloid differentiation factor 88 in miiuy croaker
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
Pattern recognition receptors can recognize pathogens, and then cells are induced to produce pro-inflammatory cytokines and interferon by multiple signaling pathways. Nevertheless, excessive inflammation disrupts immune homeostasis, thereby inducing autoimmune and inflammatory diseases. Thus, the regulation of immune responses is extremely important for host to keep homeostasis. In this study, we found that miR-19a plays a negative regulator in MyD88-mediated NF-κB signaling pathway by targeting MyD88 in miiuy croaker. Furthermore, over-expression of miR-19a in macrophages suppresses the expression of MyD88 and its downstream signaling genes of IRAK1, IRAK4 and TRAF6, whereas, the inhibitor of miR-19a has opposite effect. This study can increase our knowledge and help us to furthermore understand miRNAs regulatory mechanism in teleost fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 87, October 2018, Pages 171-175
Journal: Developmental & Comparative Immunology - Volume 87, October 2018, Pages 171-175
نویسندگان
Xueyan Zhao, Qing Chu, Junxia Cui, Tianjun Xu,