کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8498535 | 1553599 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SVCV impairs mitochondria complex â
¢ resulting in accumulation of hydrogen peroxide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: SVCV impairs mitochondria complex â
¢ resulting in accumulation of hydrogen peroxide SVCV impairs mitochondria complex â
¢ resulting in accumulation of hydrogen peroxide](/preview/png/8498535.png)
چکیده انگلیسی
Spring viraemia of carp virus (SVCV) is a deadly pathogen of common carp. SVCV infection is found to be associated with excess reactive oxygen species (ROS) generation and induces oxidative stress in EPC and FHM cells, which contributes to its pathogenesis. In this study, ROS production and mitochondria function as well as antioxidant enzymes in mitochondria were investigated during SVCV infection in EPC cells. Dysfunction of mitochondria and inactivation of mitochondria electron transport chain complex â
¢ to augment O2ââ and H2O2 accumulation were observed in SVCV infected EPC cells. Treatment of Antimycin A reduced the activity of mitochondria complex â
¢ in EPC cells, which also inhibited the transcription of SVCV glycoprotein gene (SVCV-G) and production of SVCV. Our studies explain the production of ROS following SVCV infection and also suggest that integrate mitochondrial function is important for SVCV infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 75, April 2018, Pages 58-65
Journal: Fish & Shellfish Immunology - Volume 75, April 2018, Pages 58-65
نویسندگان
Lutan Zhao, Lin Qi, Cong Li, Lijuan Li, Ling Jin, Junfa Yuan,