کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8508957 | 1556007 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ketorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivative (DR) or difference ratio (R.D), delta absorbance (ÎA) and finally convolution of derivative data using discrete Fourier functions (FFD). In the binary mixture, KTC is assayed using D0, D1 and ÎA methods with no interference from PHE, while PHE needed some spectroscopic treatments for its analysis due to the spectral overlap of KTC with its maximum wavelength (λmax) at 273â¯nm. Such treatments involve D1 R.D, D2R, FFD2 and ÎA methods. In the ternary mixture, KTC is assayed using D0 and D1 with no interference from both PHE and CPM, while R.D, D1R and FFD2 are used to assay both PHE and CPM to resolve the overlap in their spectra. Linear regression lines were obtained over the concentration ranges 1-18 and 6-48â¯Î¼g.mLâ1 for KTC and PHE (binary mixture), respectively and 2-9, 1-18 and 2-9â¯Î¼g.mLâ1 for CPM, KTC and PHE (ternary mixture), respectively yielding high correlation coefficients values (higher than 0.999). The lowest LOQ value for KTC (0.46â¯Î¼g.mLâ1) was obtained upon using the D1 method in the binary mixture while the R.D method yielded the lowest LOQ values for both PHE (0.34â¯Î¼g.mLâ1) and CPM (0.97â¯Î¼g.mLâ1) in the ternary mixture.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 56, Issue 1, June 2018, Pages 91-100
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 56, Issue 1, June 2018, Pages 91-100
نویسندگان
Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. Hamdy,