کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8515052 | 1556513 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of a Novel Form of Gelatin With a Three-Dimensional Ordered Macroporous Structure to Regulate the Release of Poorly Water-Soluble Drugs
ترجمه فارسی عنوان
آماده سازی یک شکل رمان ژلاتین با ساختاری بزرگ و مرتب شده سه بعدی برای تنظیم انتشار مواد مخدر حاوی آب حلال
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کلمات کلیدی
Sustained release - آزادی پایدارBiomaterials - بیومتریال، بیومواد Polymeric drug carrier - حامل مواد مخدر پلیمریbiodegradability - زیست تخریب پذیریThree-dimensional ordered macroporous - سه بعدی، بزرگنمایی می شودMaterials science - علم مواد یا دانش موادBioavailability - فراهم زیستیNanotechnology - فناوری نانوFenofibrate - فنوفیبراتGelatin - ژلاتین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
In this study, a novel three-dimensional ordered macroporous gelatin (3DOMG) was fabricated as a carrier for increasing the solubility of poorly water-soluble drugs, offering sustained release and a high oral bioavailability. Polymethyl methacrylate nanospheres (257 nm) were used as a colloidal plastic framework to synthesize 3DOMG. Fenofibrate (FNB) was selected as a model drug and loaded onto 3DOMG by the adsorption equilibrium method. Detailed characterization showed that the FNB absorbed onto 3DOMG was in a microcrystalline state. A fluorescence experiment and the prepared drug microcrystal network gave further information on the physical state of the drug. A degradation experiment proved that 3DOMG was readily biodegradable. In vitro release testing showed that 3DOMG increased the dissolution rate of FNB and produced a sustained release. An in vivo pharmacokinetic study confirmed that 3DOMG improved the oral bioavailability compared with that of commercial sustained-release capsules. These findings confirm that 3DOMG can be regarded as a promising carrier for an oral drug delivery system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 9, September 2016, Pages 2940-2948
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 9, September 2016, Pages 2940-2948
نویسندگان
Jie Xu, Zongzhe Zhao, Yanna Hao, Ying Zhao, Yang Qiu, Jie Jiang, Tong Yu, Peng Ji, Ying Liu, Chao Wu,