کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8524851 | 1557939 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Emerging role of sperm-associated antigen 9 in tumorigenesis
ترجمه فارسی عنوان
نقش جدیدی از آنتی ژن 9 مرتبط با اسپرم در تومور زایی
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Sperm-associated antigen 9 (SPAG9) is a new member of cancer testis antigen and belongs to c-Jun NH2-terminal kinase (JNK) interacting protein (JIP) family. SPAG9 is highly expressed in a variety of tumors patients, and induces immune response in the host. SPAG9 regulates JNK and mitogen-activated protein kinases (MAPKs) signaling pathways which promote the growth, metastasis and drug resistance of tumors. In addition, SPAG9 modulates cell cycle progression and upregulates matrix metalloproteinases during the progression of tumors. Silencing SPAG9 expression could suppress the development of tumors. This review summarizes recent progress in our understanding of the emerging role of SPAG9 in tumorigenesis and highlights the potential of SPAG9 as a novel target for cancer diagnosis and therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 103, July 2018, Pages 1212-1216
Journal: Biomedicine & Pharmacotherapy - Volume 103, July 2018, Pages 1212-1216
نویسندگان
Jun Pan, Haiyuan Yu, Zhicheng Guo, Quhe Liu, Meng Ding, Kai Xu, Lijun Mao,