کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537232 | 1561007 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrative analysis of genome-wide association study and brain region related enhancer maps identifies biological pathways for insomnia
ترجمه فارسی عنوان
تجزیه و تحلیل یکپارچه از تحقیقات ارتباط گسترده ژنوم و نقشه های تقویت کننده مربوط به منطقه مغز، مسیرهای بیولوژیکی بی خوابی را شناسایی می کند
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کلمات کلیدی
بیخوابی، تقویت کننده، بررسی ارتباط ژنوم، تجزیه و تحلیل غنی سازی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Insomnia is a common sleep disorder whose genetic mechanism remains unknown. The aim of this study is to identify novel genes, gene enrichment sets and enriched tissue/cell types for insomnia considering the differences across different brain regions. We conducted an integrative analysis of genome-wide association study (GWAS) and brain region related enhancer maps. Summary data was derived from a large-scale GWAS of insomnia, involving 113,006 unrelated individuals. The chromosomal enhancer maps of 6 brain regions were then aligned with the GWAS summary data to obtain the association testing results of enhancer regions for insomnia. Gene prioritization, tissue/cell and pathway enrichment analysis were implemented by Data-driven Expression Prioritized Integration for Complex Traits (DEPICT) tool. We identified multiple cross-brain regions or brain-region specific prioritized genes for insomnia, such as MADD (Pâ¯=â¯.0013 in angular gyrus), PPP2R3C (Pâ¯=â¯.0319 in cingulate gyrus), CASP9 (Pâ¯=â¯.0066 in angular gyrus and Pâ¯=â¯.0278 in hippocampus middle), PLEKHM2 (Pâ¯=â¯.0032 in angular gyrus, Pâ¯=â¯.0052 in anterior caudate, Pâ¯=â¯.0385 in cingulate gyrus and Pâ¯=â¯.0011 in inferior temporal lobe). This study also detected a group of insomnia associated biological pathways within multiple or specific brain regions, such as REACTOME_SIGNALING_BY_NOTCH and KEGG_GLYCEROPHOSPHOLIPID_METABOLISM. Our results showed that insomnia associated genes were significantly enriched in neural stem cells. Our results highlight a set of potential points, particularly neural stem cells, for subsequent biological studies for insomnia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 86, 30 August 2018, Pages 180-185
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 86, 30 August 2018, Pages 180-185
نویسندگان
Miao Ding, Ping Li, Yan Wen, Yan Zhao, Bolun Cheng, Lu Zhang, Mei Ma, Shiqiang Cheng, Li Liu, Yanan Du, Xiao Liang, Awen He, Xiong Guo, Feng Zhang,