کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537669 | 1561022 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simvastatin enhances the hippocampal klotho in a rat model of streptozotocin-induced cognitive decline
ترجمه فارسی عنوان
سیمواستاتین کلوتی هیپوکامپ را در یک مدل موش از کاهش شناختی ناشی از استرپتوزوتوسین افزایش می دهد
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کلمات کلیدی
GAPDHRT-PCRMWMICV-STZDMSO - DMSOAlzheimer - آلزایمرcognitive impairment - اختلال شناختیAlzheimer's disease - بیماری آلزایمرDimethyl sulfoxide - دیمتیل سولفواکسیدmanganese superoxide dismutase - سوپر اکسید دیسموتاز منگنزMorris water maze - ماز آب آب موریسreverse transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز رونویسی معکوسKlotho - کلوتوglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Brain oxidative status is a crucial factor in the development of sporadic Alzheimer's disease (AD). Klotho, an anti-aging protein, diminishes oxidative stress by the induction of manganese superoxide dismutase (MnSOD). Thus, the substances that increase klotho expression could be considered as a potential treatment for Alzheimer's disease when the oxidative imbalance is present. Statins are suggested to up-regulate klotho expression. We examined the effect of simvastatin (5Â mg/kg, daily for 3Â weeks) on hippocampal klotho and MnSOD expression in the cognitive declined animal model induced by intracerebroventricular (ICV)-streptozotocin (STZ) administration. Cognitive assessment was performed by the Morris Water Maze (MWM) test. The results indicated that mean escape latency and distance were prolonged in the ICV-STZ group compared with the control group. The expression of klotho and MnSOD were also down regulated in the hippocampus. Furthermore, improved spatial performance was observed in simvastatin-treated animals. This effect could be related to increase in oxidative stress tolerance as evidenced by klotho and MnSOD up-regulation. Our current study indicates that klotho upregulation may be a neuroprotective mechanism of simvastatin against cognitive decline in AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 72, 4 January 2017, Pages 87-94
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 72, 4 January 2017, Pages 87-94
نویسندگان
Soheila Adeli, Maryam Zahmatkesh, Gholamreza Tavoosidana, Morteza Karimian, Gholamreza Hassanzadeh,