Staphylococcus aureus TMPK and TK showing distinct structural differences with human TMPK and TK - A probable explanation in the pathogenesis

S. aureus phosphorylates only L enantiomer of dTMP while human TMPK selectively phosphorylates the D enantiomer of dTMP and its analogs probably explains this enzyme of S. aureus specific target for the development of new antimicrobial agents and conspicuous absence of human TK in active cells probably explains the rapid proliferation of S. aureus in human host.