کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545802 | 1561682 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidence that the radioprotector effect of ascorbic acid depends on the radiation dose rate
ترجمه فارسی عنوان
شواهدی وجود دارد که اثر محافظتی رادرفورد اسید آسکوربیک به میزان دوز تابش بستگی دارد
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Many studies have revealed that ascorbic acid (Aa) acts as a powerful inhibitor of genetic damage. The objetive of the present study was to evaluate the radioprotector effect of Aa at two diferent radiation dose rates. The somatic mutation and recombination test in Drosophila melanogaster was used. 48âh larvae were treated for 24âh with 25, 50 and 100âmM of Aa. After pretreatment, larvae were irradiated with 20âGy of gamma rays administered at 36 or 960âGy/h. Toxicity, development rate and frequency of mutant spots were recorded. Results provide evidence of a radioprotective effect for all tested concentrations of Aa only when 20âGy were delivered at 36âGy/h and only with 25âmM using the 960âGy/h. To consider the use of Aa as radioprotector or therapeutic agent, it is necessary to know its potential under different situations to avoid unwanted injuries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 210-214
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 210-214
نویسندگان
Elena González, Martha P. Cruces, Emilio Pimentel, Petra Sánchez,