کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550687 | 1562071 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abstinence following toluene exposure increases anxiety-like behavior in mice
ترجمه فارسی عنوان
رعب و وحشت پس از قرار گرفتن در معرض تولوئن باعث افزایش رفتار اضطرابی در موش می شود
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کلمات کلیدی
حلال های آلی (تولوئن)، برداشت از حساب، اضطراب، موش،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The intentional misuse of volatile solvents like toluene is a persistent public health concern. Limited clinical data suggest that chronic inhalant abusers may experience signs of withdrawal, including anxiety. Behavioral withdrawal from toluene has not been examined in a preclinical model. In the current study, young adult male Swiss Webster mice were exposed to either 5000-ppm toluene vapor or air (0Â ppm) for 30Â min or 24Â h. Mice were tested in a battery of four behavioral tasks reflective of anxiety either immediately (0Â h), 24Â h, or 72Â h after the toluene exposure. Mice exposed briefly (30Â min) to toluene showed decreases in anxiety-like behaviors, whereas mice abstinent from toluene for 24Â h after a prolonged (24-h) exposure, displayed increases in anxiety-like behaviors. These increases in anxiety-like behavior were not observed 72Â h post toluene. However, a brief re-exposure to toluene (30Â min at 5000Â ppm) immediately before testing 24Â h after the prolonged exposure ameliorated behavioral differences on the plus maze task. These results of 1) decreased anxiety-like behavior immediately following acute toluene, and 2) the contrasting increase in anxiety-like behavior during abstinence from a prolonged toluene exposure, and 3) the amelioration of increases in an anxiety-like behavior following toluene re-exposure, are consistent with an interpretation of withdrawal from the single 24-hr toluene exposure. These findings support clinical reports of increased anxiety during abstinence following periods of toluene use/abuse. The results also imply that experiencing anxiety during withdrawal from toluene may contribute to the persistent use of inhalants and may be relevant to clinical treatment of inhalant abuse/addiction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 65, JanuaryâFebruary 2018, Pages 42-50
Journal: Neurotoxicology and Teratology - Volume 65, JanuaryâFebruary 2018, Pages 42-50
نویسندگان
Scott E. Bowen, John H. Hannigan, Cameron J. Davidson, Sean P. Callan,