کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8550687 1562071 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abstinence following toluene exposure increases anxiety-like behavior in mice
ترجمه فارسی عنوان
رعب و وحشت پس از قرار گرفتن در معرض تولوئن باعث افزایش رفتار اضطرابی در موش می شود
کلمات کلیدی
حلال های آلی (تولوئن)، برداشت از حساب، اضطراب، موش،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The intentional misuse of volatile solvents like toluene is a persistent public health concern. Limited clinical data suggest that chronic inhalant abusers may experience signs of withdrawal, including anxiety. Behavioral withdrawal from toluene has not been examined in a preclinical model. In the current study, young adult male Swiss Webster mice were exposed to either 5000-ppm toluene vapor or air (0 ppm) for 30 min or 24 h. Mice were tested in a battery of four behavioral tasks reflective of anxiety either immediately (0 h), 24 h, or 72 h after the toluene exposure. Mice exposed briefly (30 min) to toluene showed decreases in anxiety-like behaviors, whereas mice abstinent from toluene for 24 h after a prolonged (24-h) exposure, displayed increases in anxiety-like behaviors. These increases in anxiety-like behavior were not observed 72 h post toluene. However, a brief re-exposure to toluene (30 min at 5000 ppm) immediately before testing 24 h after the prolonged exposure ameliorated behavioral differences on the plus maze task. These results of 1) decreased anxiety-like behavior immediately following acute toluene, and 2) the contrasting increase in anxiety-like behavior during abstinence from a prolonged toluene exposure, and 3) the amelioration of increases in an anxiety-like behavior following toluene re-exposure, are consistent with an interpretation of withdrawal from the single 24-hr toluene exposure. These findings support clinical reports of increased anxiety during abstinence following periods of toluene use/abuse. The results also imply that experiencing anxiety during withdrawal from toluene may contribute to the persistent use of inhalants and may be relevant to clinical treatment of inhalant abuse/addiction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 65, January–February 2018, Pages 42-50
نویسندگان
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