کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8607549 | 1567011 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation
ترجمه فارسی عنوان
مقایسه درمان پروتون با شدت مدولاسیون با استفاده از روش فوتون تشدید شده برای سرطان اپی فارنژیال: سفر از مفهوم آزمایش بالینی تا فعال شدن
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Intensity-modulated proton therapy minimizes the incidental irradiation of normal tissues in patients with head and neck cancer relative to intensity-modulated photon (x-ray) therapy and has been associated with lesser treatment-related toxicity and improved quality of life. A phase II/III randomized trial sponsored by the US National Cancer Institute is currently underway to compare deintensification treatment strategies with intensity-modulated proton therapy vs intensity-modulated photon (x-ray) therapy for patients with advanced-stage oropharyngeal tumors. After significant input from numerous stakeholders, the phase III portion of the randomized trial was redesigned as a noninferiority trial with progression-free survival as the primary endpoint. The process by which that redesign took place is described here.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Radiation Oncology - Volume 28, Issue 2, April 2018, Pages 108-113
Journal: Seminars in Radiation Oncology - Volume 28, Issue 2, April 2018, Pages 108-113
نویسندگان
Steven J. MD, Pierre MD, PhD, J. Jack PhD, Erich M. MD, MPH, Merrill S. MD, Mitchell MD, Bhadrasain MD, Adam S. MD, David I. MD, G. Brandon MD, C. David MD, PhD, Katherine PhD, Stephen MD, PhD, Paul M. MD, PhD, Nancy Y. MD, Alexander MD, Robert L. MD,