Soluble ST2, a preeclampsia-related cytokine receptor, is transported bi-directionally across the placenta

Soluble ST2 could be bi-directionally transported across placentas. It was an active process that maintained a higher level of sST2 in the maternal circulation. Furthermore, the significant increase of sST2 in the maternal blood of PE patients was due to an impaired placental barrier as a result of PE.