کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8628869 | 1568702 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression analysis of cytokine coding genes in epileptic patients
ترجمه فارسی عنوان
تجزیه و تحلیل بیان ژن های کدون سازی سیتوکین در بیماران مبتلا به صرع
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Epilepsy is a chronic disorder in which immune dysregulation is shown to be involved. Imbalances in the cytokine levels both in serum and brain tissue have been demonstrated in epileptic patients. In the present study, we assessed mRNA expression of TNF-α, TGF-β, IFN-γ, CXCL8, IL-1β, IL-2, 1L-4, IL-6, IL-17 and CXCL8 in blood samples of 40 epileptic patients compared with age- and sex-matched healthy controls by means of quantitative real time PCR. The relative levels of CXCL8 transcripts were significantly higher in total epileptic patients compared with healthy subjects (Pâ¯=â¯.023). Relative mRNA expression of IFN-γ was significantly higher in female patients compared with female healthy subject (Pâ¯=â¯.048). In addition, significant correlations have been found between the mRNA levels of mentioned cytokines. Such imbalance between expression of pro-inflammatory and anti-inflammatory cytokines might be implicated in the pathogenesis of epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 110, October 2018, Pages 284-287
Journal: Cytokine - Volume 110, October 2018, Pages 284-287
نویسندگان
Mehrdokht Mazdeh, Mir Davood Omrani, Arezou Sayad, Alierza Komaki, Shahram Arsang-Jang, Mohammad Taheri, Soudeh Ghafouri-Fard,