کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8629109 1568708 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of interleukin 13 gene polymorphisms and plasma IL 13 level with risk of systemic lupus erythematosus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Association of interleukin 13 gene polymorphisms and plasma IL 13 level with risk of systemic lupus erythematosus
چکیده انگلیسی
Interleukin (IL) 13 plays a critical role in inflammatory diseases, including systemic lupus erythematosus (SLE). This study aims to explore the potential association of IL-13 polymorphisms with the risk of SLE. We genotyped IL-13 rs20541, rs848 and rs1295686 using Snapshot SNP genotyping assays. Plasma IL-13 level was determined by enzyme-linked immunosorbent assay (ELISA). We found that rs20541 was associated with increased risk of SLE (CT vs. CC: adjusted OR = 1.43, 95%CI, 1.04-1.99, P = .030; TT vs. CC: adjusted OR = 1.73, 95%CI, 1.10-2.73, P = .018; CT/TT vs. CC: adjusted OR = 1.50, 95%CI, 1.10-2.04, P = .010; T vs. C adjusted OR = 1.34, 95%CI, 1.08-1.93, P = .031). CT and TT genotypes in rs20541 were associated with increased risk of renal disorder in SLE (CT vs. CC: adjusted OR = 1.97, 95%CI, 1.18-3.28, P = .009; TT vs. CC: adjusted OR=2.42, 95%CI, 1.22-4.77, P = .011). Moreover, The concentration of IL-13 was significantly elevated in rs20541 CT/TT genotypes compared with CC genotype (P < .001). These results suggest that rs20541 CT/TT genotypes may be a risk factor for SLE, probably by increasing the level of IL-13.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 104, April 2018, Pages 92-97
نویسندگان
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