کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8629109 | 1568708 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of interleukin 13 gene polymorphisms and plasma IL 13 level with risk of systemic lupus erythematosus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
Interleukin (IL) 13 plays a critical role in inflammatory diseases, including systemic lupus erythematosus (SLE). This study aims to explore the potential association of IL-13 polymorphisms with the risk of SLE. We genotyped IL-13 rs20541, rs848 and rs1295686 using Snapshot SNP genotyping assays. Plasma IL-13 level was determined by enzyme-linked immunosorbent assay (ELISA). We found that rs20541 was associated with increased risk of SLE (CT vs. CC: adjusted ORÂ =Â 1.43, 95%CI, 1.04-1.99, PÂ =Â .030; TT vs. CC: adjusted ORÂ =Â 1.73, 95%CI, 1.10-2.73, PÂ =Â .018; CT/TT vs. CC: adjusted ORÂ =Â 1.50, 95%CI, 1.10-2.04, PÂ =Â .010; T vs. C adjusted ORÂ =Â 1.34, 95%CI, 1.08-1.93, PÂ =Â .031). CT and TT genotypes in rs20541 were associated with increased risk of renal disorder in SLE (CT vs. CC: adjusted ORÂ =Â 1.97, 95%CI, 1.18-3.28, PÂ =Â .009; TT vs. CC: adjusted OR=2.42, 95%CI, 1.22-4.77, PÂ =Â .011). Moreover, The concentration of IL-13 was significantly elevated in rs20541 CT/TT genotypes compared with CC genotype (PÂ <Â .001). These results suggest that rs20541 CT/TT genotypes may be a risk factor for SLE, probably by increasing the level of IL-13.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 104, April 2018, Pages 92-97
Journal: Cytokine - Volume 104, April 2018, Pages 92-97
نویسندگان
Rong Wang, Yu-Lan Lu, Hua-Tuo Huang, Hai-Mei Qin, Yan Lan, Jun-Li Wang, Chun-Fang Wang, Ye-Sheng Wei,