The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice?

- The incidence of ischemic heart failure has diminished with the adoption of percutaneous coronary intervention.
- The landmark EPHESUS study established eplerenone in the management of patients with acute myocardial infarction and a left ventricular ejection fraction <40%.
- The applicability of EPHESUS and therefore eplerenone in the current era of interventional cardiology is controversial.