Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

► Low dose dextromethorphan attenuates autoimmune CNS inflammation ► Inhibits expression and activity of NOX2 ► Suppresses infiltration of peripheral immune cells into the CNS ► Reduces demyelination and axonal loss ► May be a new, inexpensive strategy for treating multiple sclerosis