کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8689012 | 1580955 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Medio-dorsal thalamus and confabulations: Evidence from a clinical case and combined MRI/DTI study
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کلمات کلیدی
DTIConfabulationFMRIB's Integrated Registration and Segmentation ToolMNIMDNFMRIB's Linear Image Registration ToolSUSANFNIRTATRACCBrain extraction tool - ابزار استخراج مغزMRI - امآرآی یا تصویرسازی تشدید مغناطیسیFIRST - اولینAcoA - بلوطdiffusion tensor imaging - تصویربرداری تانسور انتشارMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیecho time - زمان اکوRepetition time - زمان تکرارFAST - سریعKorsakoff syndrome - سندرم KorsakoffBET - شرطAnterior communicating artery - شریان ارتباطی قدامیFLIRT - طلوعanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیfractional anisotropy - ناپیوستگی کسریanterior thalamic nuclei - هسته تالام قدامیAmnesia - یاد زدودگی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The Medio-Dorsal Nuclei (MDN) including the thalamic magnocellular and parvocellular thalamic regions has been implicated in verbal memory function. In a 77Â year old lady, with a prior history of a clinically silent infarct of the left MDN, we observed the acute onset of spontaneous confabulations when an isolated new infarct occurred in the right MDN. The patient and five age-matched healthy subjects underwent Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI). The thalamic lesions were localized by overlapping Morel Thalamic Atlas with structural MRI data. DTI was used to assess: i) white matter alterations (Fractional Anisotropy, FA) within fibers connecting the ischemic areas to cortex; ii) the micro-structural damage (Mean Diffusivity) within the thalamic sub-regions defined by their structural connectivity to the Anterior Cingulate Cortex (ACC) and to the temporal lobes. These target regions were chosen because their damage is considered associated with the appearance of confabulations. Thalamic lesions were localized within the parvocellular regions of the right and left MDNs. The structural connectivity study showed that the fiber tracts, connecting the bilaterally damaged thalamic regions with the frontal cortex, corresponded to the anterior thalamic radiations (ATR). FA within these tracts was significantly lower in the patient as compared to controls. Mean diffusivity within the MDNs projecting to Broadman area (BA) 24, BA25 and BA32 of ACC was significantly higher in the patient than in control group. Mean diffusivity values within the MDN projecting to temporal lobes in contrast were not different between patient and controls. Our findings suggest the involvement of bilateral MDNs projections to ACC in the genesis of confabulations and help provide clarity to the longstanding debate on the origin of confabulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 12, February 2016, Pages 776-784
Journal: NeuroImage: Clinical - Volume 12, February 2016, Pages 776-784
نویسندگان
Valeria Onofrj, Stefano Delli Pizzi, Raffaella Franciotti, John-Paul Taylor, Bernardo Perfetti, Massimo Caulo, Marco Onofrj, Laura Bonanni,