Les agrégats d'alpha-synucléine : un biomarqueur du diagnostic et du pronostic des synucléinopathies ?

The neuropathological hallmark of Parkinson's disease is the presence of intraneuronal accumulation of aggregated alpha-synuclein. These inclusions are not confined to the central nervous system, but have also been reported in peripheral tissues. Some of these tissues, such as the gastrointestinal tract, the skin and the submandibular glands are accessible to biopsies, making them a putative original source of biomarkers. In this review, we discuss the usefulness and limitation of peripheral biopsies as a biomarker for disease diagnosis and prognosis in Parkinson's disease and other synucleinopathies.