کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8694669 | 1581725 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cell-spray auto-grafting technology for deep partial-thickness burns: Problems and solutions during clinical implementation
ترجمه فارسی عنوان
فن آوری خودکار جراحی سلول اسپری برای سوختگی عمیق ضخیم عمیق: مشکلات و راه حل ها در طول اجرای بالینی
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کلمات کلیدی
IRBDSSTTBSASTSGWound Healing - التیام زخمTotal body surface area - سطح کل بدنStem cells - سلول های بنیادیBurns - سوختگیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیRinger’s lactate - لاکتات رینگرinstitutional review board - هیئت بررسی نظارتSkin - پوستSplit-thickness skin grafts - پیوند پوست ضخیم پوستKeratinocytes - کراتینوسیت
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی
Cell-spray autografting is an innovative early treatment option for deep partial-thickness burn wounds. As an alternative to non-operative management, cell-spray autografting can achieve rapid wound re-epithelialization, particularly in large wounds. When compared to traditional mesh autografting for deep partial-thickness burn wounds, cell-spray autografting can accomplish re-epithelialization with a much smaller donor site. In this review, we describe the development of a biomedical engineering method for isolation and immediate distribution of autologous, non-cultured, adult epidermis-, and adult dermis-derived stem cells. We present data on cell isolation procedures in 44 patients with deep partial-thickness burns performed over five years under an innovative practice IRB. Treated patients presented with a variety of burn wound etiologies and a wide range of TBSA. Overall clinical results were very satisfying. The average hospital length of stay following treatment was seven days. Over the time period, the donor-site to burn-wound surface area ratio was enhanced from 1:80 to 1:100. A detailed analysis of all process-related biotechnology and operative problems, pitfalls, and solutions was performed and is reported herein. Strategies for future clinical studies are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 44, Issue 3, May 2018, Pages 549-559
Journal: Burns - Volume 44, Issue 3, May 2018, Pages 549-559
نویسندگان
Roger Esteban-Vives, Alain Corcos, Myung S. Choi, Matthew T. Young, Patrick Over, Jenny Ziembicki, Jörg C. Gerlach,