کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8696757 | 1583683 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinicopathological features of squamous cell carcinoma of the oral cavity and oropharynx in young patients
ترجمه فارسی عنوان
ویژگی های کلینیکوپاتولوژیک کارسینوم سلول سنگفرشی حفره دهان و اوروفارنکس در بیماران جوان
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی
Our aim was to examine the clinicopathological features of squamous cell carcinoma (SCC) of the oral cavity and oropharynx in a group of young patients who were dignosed during a 15-year period (2000-2014). Patients' clinical details, risk factors, and survival were obtained from medical records. Formalin-fixed, paraffin-embedded, tissue was tested for high-risk human papillomavirus (HPV). The results were compared with those of a matching group of older patients. We identified 91 patients who were younger than 45 years old, and the 50 youngest patients were studied in detail. The male:female ratio was 2:1, with more tumours located in the oral cavity than in the oropharynx (35 compared with 15). HPV-related SCC was restricted to the oropharynx. When matched for site, stage and HPV status, five-year overall survival was similar in young and matched older patients (log-rank test, p = 0.515). Our findings suggest that young patients with oral SCC have a disease profile similar to that of older patients with the condition. It is plausible that prognostic information generally available for oral cancers is applicable to young patients with the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: British Journal of Oral and Maxillofacial Surgery - Volume 56, Issue 4, May 2018, Pages 332-337
Journal: British Journal of Oral and Maxillofacial Surgery - Volume 56, Issue 4, May 2018, Pages 332-337
نویسندگان
R.C.-P. Martinez, H.P. Sathasivam, B. Cosway, V. Paleri, S. Fellows, J. Adams, M. Kennedy, R. Pearson, A. Long, P. Sloan, M. Robinson,