کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8716215 1587880 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Yin and Yang in Epithelial Immunology: The Roles of the αE(CD103)β7 Integrin in T Cells
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
A Yin and Yang in Epithelial Immunology: The Roles of the αE(CD103)β7 Integrin in T Cells
چکیده انگلیسی
The proper function(s) of cell-surface receptors is crucial for the regulation of adaptive immune responses. One such receptor is the αE(CD103)β7 integrin, whose history in science is closely linked with the evolution of our knowledge of immune regulation. Initially described as a marker of intraepithelial T-lymphocytes, this leukocyte integrin is now seen as a dynamically regulated receptor involved in the functional differentiation of some cytotoxic T cells as well as regulatory T cells, thus presumably contributing to the fine-tuning of immune reactions in epithelial compartments. In this brief overview, we delineate our current view on αE(CD103)β7 in T-cell-mediated immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 1, January 2018, Pages 23-31
نویسندگان
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