کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8735181 1591027 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Gerbich blood group system: old knowledge, new importance
ترجمه فارسی عنوان
سیستم گروه گربیچ: دانش قدیمی، اهمیت جدید
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Antigens of the Gerbich blood group system are expressed on glycophorin C (GPC) and glycophorin D (GPD), minor sialoglycoproteins of human erythrocytes. GPC and GPD help maintain erythrocyte shape of and contributes to the stability of its membrane. There are six high-prevalence Gerbich antigens: Ge2, Ge3, Ge4, GEPL (GE10), GEAT (GE11), GETI (GE12) and five low-prevalence Gerbich antigens: Wb (GE5), Lsa (GE6), Ana (GE7), Dha (GE8), GEIS (GE9). Some Gerbich antigens (Ge4, Wb, Dha, GEAT) are expressed only on GPC, two (Ge2, Ana) are expressed only on GPD, while others (Ge3, Lsa, GEIS, GEPL, GETI) are expressed on both GPC and GPD. Antibodies recognizing GPC/GPD may arise naturally (so-called “naturally-occurring RBC antibodies”) or as the result of alloimmunization, and some of them may be clinically relevant. Gerbich antibodies usually do not cause serious hemolytic transfusion reactions (HTR); autoantibodies of anti-Ge2- or anti-Ge3 specificity can cause autoimmune hemolytic anemia (AIHA).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion Medicine Reviews - Volume 32, Issue 2, April 2018, Pages 111-116
نویسندگان
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