کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8746683 | 1223470 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar
ترجمه فارسی عنوان
توالی جداسازی کامل ژنوم از جدایه های میکوباکتریوم توبرکلوزیس مقاوم به چند دارو از میانمار
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کلمات کلیدی
توالی کامل ژنوم، مقاوم در برابر مواد مخدر، میانمار،
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Drug-resistant tuberculosis (TB) is a major health threat in Myanmar. An initial study was conducted to explore the potential utility of whole-genome sequencing (WGS) for the diagnosis and management of drug-resistant TB in Myanmar. Fourteen multidrug-resistant Mycobacterium tuberculosis isolates were sequenced. Known resistance genes for a total of nine antibiotics commonly used in the treatment of drug-susceptible and multidrug-resistant TB (MDR-TB) in Myanmar were interrogated through WGS. All 14 isolates were MDR-TB, consistent with the results of phenotypic drug susceptibility testing (DST), and the Beijing lineage predominated. Based on the results of WGS, 9 of the 14 isolates were potentially resistant to at least one of the drugs used in the standard MDR-TB regimen but for which phenotypic DST is not conducted in Myanmar. This study highlights a need for the introduction of second-line DST as part of routine TB diagnosis in Myanmar as well as new classes of TB drugs to construct effective regimens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Global Antimicrobial Resistance - Volume 6, September 2016, Pages 113-117
Journal: Journal of Global Antimicrobial Resistance - Volume 6, September 2016, Pages 113-117
نویسندگان
Htin Lin Aung, Thanda Tun, Danesh Moradigaravand, Claudio U. Köser, Wint Wint Nyunt, Si Thu Aung, Thandar Lwin, Kyi Kyi Thinn, John A. Crump, Julian Parkhill, Sharon J. Peacock, Gregory M. Cook, Philip C. Hill,