کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8817621 | 1608953 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prevalence and Risk Factors Associated with Adverse Drug Reactions among Previously Treated Tuberculosis Patients in China
ترجمه فارسی عنوان
شیوع و عوامل خطر مرتبط با واکنش های نامطلوب دارویی در بیماران مبتلا به سل ریوی پیش بیمار در چین
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کلمات کلیدی
بیماری سل، واکنشهای جانبی جانبی، داروهای ضد سل، درمان سل،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی
We assessed the incidence of adverse drug reactions (ADRs) with anti-TB medications and evaluated the risk factors for developing ADRs in previously treated tuberculosis patients in China. All patients received the first-line anti-TB regimen (2HREZS/6HRE) as recommended by the national guidelines. Clinical and laboratory evaluations were performed once a month. Out of the 354 participants, 262 (74.0%) experienced ADRs such as hyperuricemia (65.0%, 230/354), hepatotoxicity (6.2%, 22/354) and hearing disturbances (4.8%, 17/354). ADRs were significantly associated with diabetes mellitus [OR (95% CI): 15.5 (2.07-115.87)]; however, weight more than 50 kg [OR (95% CI): 0.41 (0.22-0.85)] was a protective factor for occurrence of ADRs. Hyperuricemia is the most common adverse event but, most patients with hyperuricemia showed increased tolerance for high uric acid levels. Low body weight and diabetes mellitus increased the risk of the occurrence of ADRs during anti-TB treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedical and Environmental Sciences - Volume 30, Issue 2, February 2017, Pages 139-142
Journal: Biomedical and Environmental Sciences - Volume 30, Issue 2, February 2017, Pages 139-142
نویسندگان
Xi Qin HAN, Yu PANG, Yan MA, Yu Hong LIU, Ru GUO, Wei SHU, Xue Rui HUANG, Qi Ping GE, Jian DU, Wei Wei GAO,