کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8868813 | 1622536 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Size dependent oxidative stress response of the gut of Daphnia magna to functionalized nanodiamond particles
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Nanodiamonds are a type of engineered nanomaterial with high surface area that is highly tunable and are being proposed for use as a material for medical imaging or drug delivery to composites. With their potential for widespread use they may potentially be released into the aquatic environment as are many chemicals used for these purposes. It is generally thought that nanodiamonds are innocuous, but toxicity may occur due to surface functionalization. This study investigated the potential oxidative stress and antioxidant response of enterocytes in a freshwater invertebrate, Daphnia magna, a common aquatic invertebrate for ecotoxicological studies, in response to two types of functionalized nanodiamonds (polyallylamine and oxidized). We also examined how the size of the nanomaterial may influence toxicity by testing two different sizes (5â¯nm and 15â¯nm) of nanodiamonds with the same functionalization. Adults of Daphnia magna were exposed to three concentrations of each of the nanodiamonds for 24â¯h. We found that both 5 and 15â¯nm polyallylamine nanodiamond and oxidized nanodiamond induced the production of reactive oxygen species in tissues. The smaller 5â¯nm nanodiamond induced a significant change in the expression of heat shock protein 70 and glutathione-S-transferase. This may suggest that daphnids mounted an antioxidant response to the oxidative effects of 5â¯nm nanodiamonds but not the comparative 15â¯nm nanodiamonds with either surface chemistry. Outcomes of this study reveal that functionalized nanodiamond may cause oxidative stress and may potentially initiate lipid peroxidation of enterocyte cell membranes in freshwater organisms, but the impact of the exposure depends on the particle size.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 167, November 2018, Pages 267-275
Journal: Environmental Research - Volume 167, November 2018, Pages 267-275
نویسندگان
Gustavo A. DomÃnguez, Marco D. Torelli, Joseph T. Buchman, Christy L. Haynes, Robert J. Hamers, Rebecca D. Klaper,