کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8920168 1643342 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Return to the hematopoietic stem cell origin
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Return to the hematopoietic stem cell origin
چکیده انگلیسی
Studying embryonic hematopoiesis is complicated by diversity of its locations in the constantly changing anatomy and by the mobility of blood cell precursors. Embryonic hematopoietic progenitors are identified in traditional in vivo and in vitro cell potential assays. Profound epigenetic plasticity of mammalian embryonic cells combined with significant inductive capacity of the potential assays suggest that our understanding of hematopoietic ontogenesis is substantially distorted. Non-invasive in vivo cell tracing methodology offers a better insight into complex processes of blood cell specification. In contrast to the widely accepted view based on the cell potential assays, the genetic tracing approach identified the yolk sac as the source of adult hematopoietic stem cell lineage. Realistic knowledge of the blood origin is critical for safe and efficient recapitulation of hematopoietic development in culture.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Regeneration - Volume 1, Issue 1, 2012, 1:9
نویسندگان
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