کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8924847 1643565 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Paratharmone related protein (peptide): A novel prognostic, diagnostic and therapeutic marker in Head & Neck cancer
ترجمه فارسی عنوان
پروتئین مرتبط با پروپارمون (پپتید): یک نشانگر پیش آگهی، تشخیصی و درمانی در سر و گردن
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی
Parathyroid hormone-related protein (PTHrP) is a promising modality of assessment of different critical features of cancer. It is a protein member of parathyroid hormone family, secreted by certain physiologic cells and by malignant tumors in an increased amount. Recent studies have confirmed that PTHrP massively contributes to malignant behaviour of oral cancers-cell proliferation, migration and invasiveness. Strong correlation was found between PTHrP overexpression and local bone invasion and percentage of tumor cells in metastatic nodes. Normal range of PTHrP in serum is 0.7-2.6 ρmol/litre. Its down-regulation blocks cell cycle of cancer cell lines and inhibits cell proliferation and colony formation. PTHrP can be used as a diagnostic aid, prognostic marker and excellent research arena for designing novel anti-neoplastic drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Stomatology, Oral and Maxillofacial Surgery - Volume 119, Issue 1, February 2018, Pages 33-36
نویسندگان
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