کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994935 | 1114475 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physicochemical and Structural Characterization of Quercetin-β-Cyclodextrin Complexes
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Physicochemical and Structural Characterization of Quercetin-β-Cyclodextrin Complexes Physicochemical and Structural Characterization of Quercetin-β-Cyclodextrin Complexes](/preview/png/8994935.png)
چکیده انگلیسی
Quercetin is a bioactive flavonoid widely used as a health supplement. Being sparingly soluble and chemically unstable in aqueous intestinal fluids, quercetin is poorly absorbed orally. This study aimed to investigate the effects of three β-cyclodextrins, namely, unsubstituted β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), and sulfobutyl ether β-cyclodextrin (SBE-β-CD) on the chemical stability and water solubility of quercetin, and to elucidate the complexation mechanisms of these β-CDs with quercetin. Quercetin-β-CD complexes in solution were characterized by stability assessment, phase solubility measurements, and 1H-nuclear magnetic resonance (NMR) spectroscopy. Molecular modeling was used to help establish the mode of interaction of the β-CDs with quercetin. Solubility enhancements of quercetin obtained with the three β-CDs followed the rank order: SBE-β-CD > HP-β-CD > β-CD. The stability of quercetin at alkaline pHs also showed substantial improvement. NMR spectroscopic analysis suggested that the B-ring, C-ring, and part of the A-ring of quercetin display favorable interaction with the hydrophobic cavity of the β-CDs, which was confirmed by molecular dynamics (MD) simulations using a solvated model of the quercetin-β-CD complex. An inclusion complex model has been established for explaining the observed augmentation of solubility and stability of quercetin in water by β-CDs. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 5, May 2005, Pages 1079-1089
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 5, May 2005, Pages 1079-1089
نویسندگان
Ying Zheng, Ian S. Haworth, Zhong Zuo, Moses S.S. Chow, Albert H.L. Chow,