کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9011316 | 1124146 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals
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کلمات کلیدی
Annona squamosaFBGHDLPPGVLDLBGLGTTSTZS.D. - SD.Alloxan - آلوکسانstreptozotocin - استرپتوزوتوسینstandard deviation - انحراف معیارDiabetes - بیماری قندtriglyceride - تریگلیسریدglucose tolerance test - تست تحمل گلوکزblood glucose level - سطح قند خونfasting blood glucose - قند خون ناشتاhigh density lipoprotein - لیپوپروتئین با چگالی بالاvery low density lipoprotein - لیپوپروتئین چگالی بسیار کم استlow density lipoprotein - لیپوپروتئین چگالی کمLDL - لیپوپروتئین کم چگالی(کلسترول بد)body weight - وزن بدنtotal cholesterol - کلسترول تامPostprandial glucose - گلوکز پس از فروپاشی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The ethanolic extract of Annona squamosa L. (Annonaceae) leaves was administered orally at different doses to normal as well as streptozotocin (STZ)-induced diabetic rats and alloxan-induced diabetic rabbits. The dose of 350Â mg/kg body weight (bw) reduced the fasting blood glucose (FBG) level by 6.0% within 1Â h, whereas, the peak blood glucose at 1Â h during glucose tolerance test (GTT) was reduced by 17.1% in normal rats. The same dose of ethanolic extract reduced FBG by 26.8% and improved glucose tolerance by 38.5 and 40.6% at 1 and 2Â h, respectively, during GTT in alloxan-induced diabetic rabbits. In STZ-diabetic rats, a fall of 13.0% in FBG and an improvement in glucose tolerance by 37.2 and 60.6% at 1 and 2Â h, respectively, was observed during GTT. The dose of 350Â mg/kg bw of ethanolic extract in 10-day treatment of a group of STZ-diabetic rats produced 73.3% fall in FBG level and no sugar was observed in fasting urine. Treatment of severely-diabetic rabbits for 15 days with a dose of 350Â mg/kg of extract reduce FBG by 52.7% and urine sugar by 75%. It brought about fall in the level of total cholesterol (TC) by 49.3% with increase of 30.3% in high-density lipoprotein (HDL) and decrease of 71.9 and 28.7% in low-density lipoprotein (LDL) and triglycerides (TG) levels, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 99, Issue 1, 13 May 2005, Pages 75-81
Journal: Journal of Ethnopharmacology - Volume 99, Issue 1, 13 May 2005, Pages 75-81
نویسندگان
Rajesh Kumar Gupta, Achyut Narayan Kesari, P.S. Murthy, R. Chandra, V. Tandon, Geeta Watal,