کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9011423 | 1124156 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypoglycemic effects of Murraya koenigii on normal and alloxan-diabetic rabbits
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کلمات کلیدی
FBGBGLGTTMurraya koenigiiUGCS.D. - SD.Alloxan - آلوکسانstandard deviation - انحراف معیارLeaves - برگهاglucose tolerance test - تست تحمل گلوکزDiabetes mellitus - دیابت قندیWorld Health Organisation - سازمان بهداشت جهانیblood glucose level - سطح قند خونaqueous extract - عصاره آبfasting blood glucose - قند خون ناشتاWHO - که
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In past there have been many medicinal plants, which have been used in traditional medicines for their antidiabetic properties without any scientific support and pharmacological evidence. The aqueous extract of Murraya koenigii leaves has been taken to evaluate the hypoglycemic activity in normal and alloxan induced diabetic rabbits. This plant is promising as it is widely and regularly used as a spice for food flavoring and as such it appears to be without any side effects and toxicity. Adequate characterization of hypoglycemic activity of aqueous extract has not been yet done, as no such reports are available in the literature though the activity is reported. The scientific evaluation of its hypoglycemic activity was, therefore, explored and also compared with the effect of a standard hypoglycemic drug, tolbutamide. A single oral administration of variable dose levels (200, 300 and 400Â mg/kg) of aqueous extract led to lowering of blood glucose level in normal as well as in diabetic rabbits. The maximum fall of 14.68% in normal and 27.96% in mild diabetic was observed after 4Â h of oral administration of 300Â mg/kg. The same dose also showed a marked improvement in glucose tolerance of 46.25% in sub-diabetic (AR) and 38.5% in mild diabetic rabbits in glucose tolerance test after 2Â h. The findings from this study suggest that the aqueous extract of these leaves may be prescribed as adjunct to dietary therapy and drug treatment for controlling diabetes mellitus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 97, Issue 2, 28 February 2005, Pages 247-251
Journal: Journal of Ethnopharmacology - Volume 97, Issue 2, 28 February 2005, Pages 247-251
نویسندگان
Achyut Narayan Kesari, Rajesh Kumar Gupta, Geeta Watal,