کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9015976 | 1127609 | 2005 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sensitization of adenylate cyclase by Gαi/o-coupled receptors
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کلمات کلیدی
PKCLMMPSuperactivationRGScdk5DARPP-32pKaCRFAGSCREBadenylate cyclase - آدنیلات سیکلاسHeterologous sensitization - حساسیت حسیRegulator of G protein signaling - رگولاتور سیگنالینگ پروتئین GDrug abuse - سوء مصرف موادcyclin-dependent kinase 5 - سیکلین وابسته به کیناز 5CAD - طراحی به کمک رایانه یا کَدcorticotrophin releasing factor - عامل آزاد کننده کورتیکوتروپینG proteins - پروتئین Gcyclic AMP response element-binding protein - پروتئین اتصال دهنده عنصر Response Cyclic AMPprotein kinase A - پروتئین کیناز AProtein kinase C - پروتئین کیناز سی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
Activation of receptors coupled to inhibitory G proteins (Gαi/o) has opposing consequences for cyclic AMP accumulation and the activity of cyclic AMP-dependent protein kinase, depending on the duration of stimulation. Acute activation inhibits the activity of adenylate cyclase, thereby attenuating cyclic AMP accumulation; in contrast, persistent activation of Gαi/o-coupled receptors produces a paradoxical enhancement of adenylate cyclase activity, thus increasing cyclic AMP accumulation when the action of the inhibitory receptor is terminated. This heterologous sensitization of cyclic AMP signaling, also called superactivation or supersensitization, likely represents a cellular adaptive response, a mechanism by which the cell compensates for chronic inhibitory input. Recent advances in our knowledge of G protein-mediated signaling, regulation of adenylate cyclase, and other cellular signaling mechanisms have extensively increased our insight into the mechanisms and significance of this phenomenon. In particular, recent evidence points to the Gαs-adenylate cyclase interface as a locus for the expression of the sensitized adenylate cyclase response, and to isoform-specific phosphorylation of adenylate cyclase as one mechanism that can produce sensitization. Gαi/o-coupled receptor-induced heterologous sensitization may contribute to enhanced Gαs-coupled receptor signaling following neurotransmitter elevations induced by the administration of drugs of abuse and during other types of neuronal function or dysfunction. This review will focus on recent advances in our understanding of signaling pathways that are involved in sensitization and describe the potential role of sensitization in neuronal function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 106, Issue 3, June 2005, Pages 405-421
Journal: Pharmacology & Therapeutics - Volume 106, Issue 3, June 2005, Pages 405-421
نویسندگان
Val J. Watts, Kim A. Neve,