کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9126950 | 1569967 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
EREUTRVitellogeninHSDRT-PCR17β-estradiol - 17β استرادیولAdipocytes - آدیپوسیتEST - استTestis - بیضهOvary - تخمدانcoding sequence - توالی کدگذاریExpressed Sequence Tag - تکرار اظهار نظرdigoxigenin - دیگوکسین ژنDIG - شماEstrogen responsive element - عنصر پاسخگو استروژنPhosvitin - فوزویتینuntranslated region - منطقه غیر ترجمهGenome mapping - نقشه برداری ژنومcrossing point - نقطه عبورreverse transcriptase polymerase chain reaction - واکنش زنجیره ای پلی مراز ترانس کریتاز معکوسvtg - ویتگCdS - کادمیم سولفید، سولفید کادمیمLiver - کبدEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio](/preview/png/9126950.png)
چکیده انگلیسی
Vitellogenins (Vtgs) are yolk precursor proteins in oviparous species and are cleaved into three portions-lipovitellin I (LVI), phosvitin (PV), and lipovitellin II (LVII)-in oocytes in vertebrates. In the present study, we found that the zebrafish genome contains at least seven vtg genes (vtg1-7) encoding heterogeneous vitellogenins with three distinct types of Vtgs: type I (Vtg1, 4-7) contains all the three major portions but lacks the C-terminal half of LVII; type II (Vtg2) is the only one including intact three portions; type III (Vtg3) lacks both PV and the LVII C-terminal half. The seven vtgs were located in two different chromosomes: one (vtg3) in LG11 and the rest closely linked in LG22, probably arisen from local gene duplication events. All of the seven vtgs are predominantly expressed in female liver and can be induced in male liver by 17β-estradiol (E2). The level of vtg1 mRNA was about 100à and 1000à higher than those of vtg2 and vtg3 mRNAs. We also found vtg mRNAs in several non-liver tissues, but the expression level is generally < 10% of that in the liver. In situ hybridization experiments confirmed that the extrahepatic expression was actually in adipocytes associated with several organs such as the intestine, ovary, and E2-induced testis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 356, 15 August 2005, Pages 91-100
Journal: Gene - Volume 356, 15 August 2005, Pages 91-100
نویسندگان
Hai Wang, Jacqueline T.T. Tan, Alexander Emelyanov, Vladimir Korzh, Zhiyuan Gong,