کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9148982 | 1166142 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of temperature on calcium sensitivity in the ventricular myocardium of the South American lungfish: Effects of extracellular calcium and adrenaline
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
The mechanical properties of ventricular myocardium of the South American lungfish, Lepidosiren paradoxa, acclimated to 25 °C, were evaluated in vitro at 15, 25 and 35 °C. The inotropism (Fc-% of initial values) of ventricle strips was examined in response to adrenaline (from 10â8 to 10â5 M) and extracellular calcium (from 2.5 to 14.5 mM) in all experimental temperatures. At 15 and 25 °C, Fc rose when extracellular Ca2+ or adrenaline were increased, while Fc remained unchanged at 35 °C. These results suggest that at lower temperatures Ca2+ availability is a limiting step to cardiac performance and can be ameliorated by adrenergic stimulation. In contrast, since inotropic agents failed to increase cardiac inotropism at 35 °C, lungfish myocytes seem to show a high temperature sensitivity, which increases Ca2+-buffering capacity and/or Ca2+ transportation from and to cytosol as well as myofilaments Ca2+ sensitivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thermal Biology - Volume 30, Issue 4, May 2005, Pages 259-266
Journal: Journal of Thermal Biology - Volume 30, Issue 4, May 2005, Pages 259-266
نویسندگان
Monica Jones Costa, Claudio Dalle Olle, Francisco Tadeu Rantin, Ana Lúcia Kalinin,