کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9179663 | 1181554 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
GSHROSCLVEDPGSSGAOPARRopen-chest cardiac compressionCardiopulmonary resuscitation - احیا قلب و عروقCPR - احیای قلبی ریویElectrocardiography - الکتروکاردیوگرافی یا قلبنگاریCardiac arrest - ایست قلبی یا آرست قلبStunning - خیره کنندهFree radical - رادیکالهای آزاد Phosphocreatine - فسفریکراتینmean aortic pressure - فشار متوسط آئورتleft ventricular end-diastolic pressure - فشار پای دیاستولیک بطن چپMetabolism - متابولیسم myocardial - میوکاردPCR - واکنش زنجیرهٔ پلیمرازcreatine - کراتینGlutathione - گلوتاتیونglutathione disulfide - گلوتاتیون دی سولفید
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitation Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitation](/preview/png/9179663.png)
چکیده انگلیسی
Severe depletion of myocardial energy and antioxidant resources during cardiac arrest culminates in electromechanical dysfunction following recovery of spontaneous circulation (ROSC). A metabolic fuel and natural antioxidant, pyruvate augments myocardial energy and antioxidant redox states in parallel with its enhancement of contractile performance of stunned and oxidant-challenged hearts. This study tested whether pyruvate improves post-arrest cardiac function and metabolism. Beagles were subjected to 5 min cardiac arrest and 5 min open-chest cardiac compression (OCCC: 80 compressions minâ1; aortic pressure 60-70 mmHg), then epicardial dc countershocks (5-10 J) were applied to restore sinus rhythm. Pyruvate was infused i.v. throughout OCCC and the first 25 min ROSC to a steady-state arterial concentration of 3.6 ± 0.2 mM. Control experiments received NaCl infusions. Phosphocreatine phosphorylation potential (â¼PCr) and glutathione/glutathione disulfide ratio (GSH/GSSG), measured in snap-frozen left ventricle, indexed energy and antioxidant redox states, respectively. In control experiments, left ventricular pressure development, dP/dt and carotid flow initially recovered upon defibrillation, but then fell 40-50% by 3 h ROSC. ST segment displacement in lead II ECG persisted throughout ROSC. â¼PCr collapsed and GSH/GSSG fell 61% during arrest. Both variables recovered partially during OCCC and completely during ROSC. Pyruvate temporarily increased â¼PCr and GSH/GSSG during OCCC and the first 25 min ROSC and enhanced pressure development, dP/dt and carotid flow at 15-25 min ROSC. Contractile function stabilized and ECG normalized at 2-3 h ROSC, despite post-infusion pyruvate clearance and waning of its metabolic benefits. In conclusion, intravenous pyruvate therapy increases energy reserves and antioxidant defenses of resuscitated myocardium. These temporary metabolic improvements support post-arrest recovery of cardiac electromechanical performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Resuscitation - Volume 66, Issue 1, July 2005, Pages 71-81
Journal: Resuscitation - Volume 66, Issue 1, July 2005, Pages 71-81
نویسندگان
Arti B. Sharma, E. Marty Knott, Jian Bi, Rodolfo R. Martinez, Jie Sun, Robert T. Mallet,