کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9227065 | 1202031 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of T regulatory cells in asthma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
As a chronic inflammatory disease, much of the research related to asthma has been focused on proinflammatory mechanisms. Recently, advances have been made in defining mechanisms that control inflammation and induce immune tolerance to specific antigens. Subsets of CD4+ cells known as T regulatory cells play an important role in directing these processes, and recent experiments have begun to define crucial molecular and signaling pathways. There is a growing body of evidence describing the function of T regulatory cells in the development, disease activity, and treatment responses related to asthma and other atopic diseases. Collectively, this new information suggests that a greater understanding of these pathways might lead to new therapeutic targets for asthma and other diseases of chronic airway inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 116, Issue 5, November 2005, Pages 996-999
Journal: Journal of Allergy and Clinical Immunology - Volume 116, Issue 5, November 2005, Pages 996-999
نویسندگان
Christine M. MD, James E. MD,