In Vivo Generation of Oligoclonal Colitic CD4+ T-Cell Lines Expressing a Distinct T-Cell Receptor Vβ

Conclusions: Colitis-inducing CD4+ T-helper 1 cell clones can be obtained by enrichment through sequential adoptive transfers of CD4+ cells from mesenteric lymph nodes. Distinct dominant T-cell receptor Vβs in each cell line responded to antigens presented by class II major histocompatibility complex.