کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9263337 | 1216030 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Postantibiotic effect of antimicrobial combinations on multidrug-resistant Pseudomonas aeruginosa
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
The application of antimicrobial combinations on multidrug-resistant Pseudomonas aeruginosa might be of clinical relevance if they possess a significant postantibiotic effect (PAE). Twenty-two nosocomial isolates were exposed over time to ceftazidime, imipenem, or ciprofloxacin, and to their interaction with amikacin; all were applied at concentrations equal to their average serum level. After 24 h of exposure, live cells were washed and resuspended into fresh broth, and bacterial growth was monitored. PAE was found only for isolates subjected to the synergistic effect of the applied interactions. For these isolates, the mean PAEs (±SE) were 3.10 ± 0.71 h for ceftazidime and amikacin, 4.38 ± 0.83 h for imipenem and amikacin, and 3.33 ± 2.83 h for ciprofloxacin and amikacin. The prolonged PAE documented after exposure to the interactions of the studied drugs strengthens the application of their combination for the management of infections by multidrug-resistant P. aeruginosa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 51, Issue 2, February 2005, Pages 113-117
Journal: Diagnostic Microbiology and Infectious Disease - Volume 51, Issue 2, February 2005, Pages 113-117
نویسندگان
Evangelos J. Giamarellos-Bourboulis, Nikolaos Kentepozidis, Anastasia Antonopoulou, Diamantis Plachouras, Thomas Tsaganos, Helen Giamarellou,