کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
930451 1474484 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EEG coherence in girls with Attention-Deficit/Hyperactivity Disorder: Stimulant effects in good responders
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
EEG coherence in girls with Attention-Deficit/Hyperactivity Disorder: Stimulant effects in good responders
چکیده انگلیسی

This study investigated the effects of stimulants on EEG coherence in girls with Attention-Deficit/Hyperactivity Disorder (AD/HD). Twenty girls with AD/HD (aged 7–12) and 20 age- and sex-matched controls had an eyes-closed resting electroencephalogram (EEG) recorded from 21 electrode sites. Coherence was calculated from eight intrahemispheric electrode pairs (four in each hemisphere), and eight interhemispheric electrode pairs, for the delta, theta, alpha and beta frequency bands. AD/HD participants were tested twice: first, prior to medication being prescribed, and second, six months later on a therapeutic dose of a stimulant. With intrahemispheric coherences at short-medium inter-electrode distances, AD/HD girls off-medication had reduced lateralisation in the delta, theta and alpha bands. They also had reduced lateralisation in the theta band for longer inter-electrode distances, and increased frontal interhemispheric coherences in all frequency bands. Medication had no impact on the laterality anomalies, but produced novel increases in intrahemispheric coherences at short-medium inter-electrode distances, which reached significance in the delta band and approached significance in the alpha band. However, these increased coherences remained indistinguishable from control levels. Reduced hemispheric lateralisations found in these AD/HD participants illustrate cortical abnormalities consistent with maturational lag explanations. The widespread elevated frontal interhemispheric coherences found in these AD/HD girls could reflect the narrow profile of female medication responders identified in clinical settings. The lack of substantial coherence medication effects in good clinical responders supports a previous medication study with AD/HD boys, and suggests that these coherence anomalies reflect structural, rather than solely functional, differences in brain development in AD/HD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Psychophysiology - Volume 70, Issue 3, December 2008, Pages 151–157
نویسندگان
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