MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates1

In the absence of HO-1, expression of MCP-1 is significantly and consistently enhanced in unstressed and stressed conditions. We speculate that the protective effects of HO-1 in injured tissue may involve, at least in part, the capacity of HO-1 to restrain up-regulation of MCP-1.