کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
936826 | 1475193 | 2010 | 11 صفحه PDF | دانلود رایگان |
Prey animals such as rats display innate defensive responses when exposed to the odor of a predator, providing a valuable means of studying the neurobiology of anxiety. While the unconditioned behavioral and neural responses to a single predator odor exposure have been well documented, the paradigm can also be used to study learning-dependent adaptations that occur following repeated exposure to a stressor or associated stimuli. In developing preclinical models for human anxiety disorders this is advantageous, as anxiety disorders seldom involve a single acute experience of anxiety, but rather are chronic and/or recurring illnesses. Part 1 of this review summarizes current research on the three most commonly used predator-related odors: cat odor, ferret odor, and trimethylthiazoline (a component of fox odor). Part 2 reviews the learning-based behavioral and neural adaptations that underlie predator odor-induced context conditioning, one-trial tolerance, sensitization, habituation and dishabituation.
Research highlights
► Predator odors are increasingly used to study the neurobiology of anxiety.
► Cat odor, ferret odor and TMT are the most commonly used predator odors.
► Predator odors produce learning-dependent neuroadaptations in anxiety models.
► These models provide new information about specific subtypes of anxiety.
Journal: Neurobiology of Learning and Memory - Volume 94, Issue 4, November 2010, Pages 435–445