کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
939471 1475398 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lactobacillus paracasei subsp paracasei L. casei W8 suppresses energy intake acutely
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Lactobacillus paracasei subsp paracasei L. casei W8 suppresses energy intake acutely
چکیده انگلیسی


• Probiotics were found to increase mRNA of the glucagon encoding gene in piglets.
• Probiotics increased the GLP-1 secretion in an isolated pig intestine.
• Participants having a probiotic capsule had a reduced energy intake.

Background: Probiotic bacteria have been shown to have various effects on the microbiota; this may also affect appetite and may help promote weight loss and maintenance. Objective: This study was conducted to investigate the effect of Lactobacillus paracasei subsp paracasei L. casei W8 (L. casei W8) on glucagon-like peptide-1 (GLP-1) responses in an isolated pig intestine, in piglets and postprandially in humans. Additionally, the effect on subjective appetite, ad libitum energy intake, and glucose and insulin responses in humans was investigated. Design: Piglets were fed with probiotics for 2 weeks and the effect on glucagon encoding gene (GCG) was investigated. An isolated pig intestine was perfused with L. casei W8 and the GLP-1 response was measured. Twenty-one subjects completed a randomized, controlled, crossover study with three arms. Each participant completed 3 test days testing the effect of low dose (LD) (109 CFU), high dose (HD) (1010 CFU) L. casei W8 or placebo capsule. Subjective appetite was assessed before an ad libitum lunch was served. GLP-1, insulin and glucose concentrations were analyzed. Results: Two weeks of treatment of piglets with L. casei W8 resulted in an increase in GCG expression compared to control animals (P < 0.05). L. casei W8 increased the GLP-1 response in the isolated pig intestine. In humans, L. casei W8 had an overall effect on energy intake (P = 0.03), but no effects on subjective appetite sensation, overall glucose and insulin response and on GLP-1 release were observed (P > 0.1). Conclusion: The probiotic bacteria L. casei W8 appears to lower food intake acutely, but the underlying mechanisms are not understood.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Appetite - Volume 82, 1 November 2014, Pages 111–118
نویسندگان
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