کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415656 | 1292936 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: An optical analysis in cultured hippocampal neurons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: An optical analysis in cultured hippocampal neurons Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: An optical analysis in cultured hippocampal neurons](/preview/png/9415656.png)
چکیده انگلیسی
Zinc chelation and non-steroidal anti-inflammatory drugs (NSAIDs) have been explored as potential neuroprotective agents. However, it remains unknown whether NSAIDs and zinc chelation may converge on a similar cellular process. Using two-photon microscopy to observe hippocampal neurons labeled with a zinc-sensitive dye, we provide evidence that three chemically unrelated NSAIDs, niflumic acid, ibuprofen, and naproxen, acutely increase intracellular zinc stores from extracellular metal pools. Phospholipase A2 inhibitors triggered similar responses, suggesting that NSAIDs likely control zinc stores by their activity as cyclooxygenase inhibitors. These results provide evidence for a new link between cyclooxygenase metabolites and the mechanisms controlling neuronal zinc pools.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1061, Issue 1, 2 November 2005, Pages 1-12
Journal: Brain Research - Volume 1061, Issue 1, 2 November 2005, Pages 1-12
نویسندگان
Rachal Love, Gloria Salazar, Victor Faundez,