کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416277 | 1614333 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Patterns of fos expression in the rostral medulla and caudal pons evoked by noxious craniovascular stimulation and periaqueductal gray stimulation in the cat
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کلمات کلیدی
vlPAGventrolateral PAGNRGcTrigeminovascularSSNVSTITNNRMSSSVMNNHSVOCVPDPAGstandard deviation - انحراف معیارphosphate buffer - بافر فسفاتSpinal trigeminal tract - تریژمنیال ستون فقراتperiaqueductal gray - خاکستری پرآبیBrainstem - ساقه مغزnormal horse serum - سرم طبیعی اسبsuperior sagittal sinus - سینوسی سرایتتال برترVOR - قبل ازMedulla - مدولاMigraine - میگرنnucleus reticularis gigantocellularis - هسته reticularis gigantocellularissuperior salivatory nucleus - هسته خوشخیم بالاnucleus raphe magnus - هسته رافا مگنTrigeminal nucleus - هسته سه هسته ایtrigeminal nucleus caudalis - هسته سه هسته ای caudalisTrigeminal motor nucleus - هسته موتور دردی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Functional imaging studies and clinical evidence suggest that structures in the brainstem contribute to migraine pathophysiology with a strong association between the brainstem areas, such as periaqueductal gray (PAG), and the headache phase of migraine. Stimulation of the superior sagittal sinus (SSS) in humans evokes head pain. Second-order neurons in the trigeminal nucleus that are activated by SSS stimulation can be inhibited by PAG stimulation. The present study was undertaken to identify pontine and medullary structures that respond to noxious stimulation of the superior sagittal sinus or to ventrolateral PAG stimulation. The distribution of neurons expressing the protein product (fos) of the c-fos immediate early gene were examined in the rostral medulla and caudal pons of the cat after (i) sham, (ii) stimulation of the superior sagittal sinus, (iii) stimulation of the superior sagittal sinus with PAG stimulation, or (iv) stimulation of the PAG alone. The structures examined for fos were the trigeminal nucleus, infratrigeminal nucleus, reticular nuclei, nucleus raphe magnus, pontine blink premotor area, and superior salivatory nucleus. Compared with all other interventions, fos expression was significantly greater in the trigeminal nucleus and superior salivatory nucleus after SSS stimulation. After PAG with SSS stimulation, on the side ipsilateral to the site of PAG stimulation, fos was significantly greater in the nucleus raphe magnus. These structures are likely to be involved in the neurobiology of migraine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1045, Issues 1â2, 31 May 2005, Pages 1-11
Journal: Brain Research - Volume 1045, Issues 1â2, 31 May 2005, Pages 1-11
نویسندگان
Yolande E. Knight, John D. Classey, Michele P. Lasalandra, Simon Akerman, Fernando Kowacs, Karen L. Hoskin, Peter J. Goadsby,